For these 136 HIV-negative patients, 62 were confirmed to have other forms of immunodeficiencies, including adult onset immunodeficiency syndrome secondary to anti-interferon gamma autoantibodies (n = 23), immunosuppressive treatment after renal or liver transplantation (n = 22), STAT3 mutation (n = 4), CD40LG mutation (n = 4), CARD9 mutation (n = 3), STAT1 mutation (n = 3), IL12RB1 mutation (n = 2), TSC2 mutation (n = 1), and IFNGR1 mutation (n = 1). This evidence concerns the gene TSC2 and acquired adult-onset immunodeficiency.