Furthermore, fusions such as SLC45A2-AMACR, ITCH-ASIP, and RNF138-RNF125 have been associated with better HCC prognoses, while MAN2A1-FER, CCNH-C5orf30, and SLC45A2-AMACR, detectable in serum, show potential for HCC diagnosis [13]. This evidence concerns the gene RNF138 and hepatocellular carcinoma.