ERBB2 and urinary bladder carcinoma: Together with the greater T-DXd sensitivity of SMBO-106 versus SMBO-170 xenografts, the data suggest that induction of cell death by the cytotoxic payload, may be a more important predictor of response to HER2-targeted ADCs in a bladder cancer context than HER2 expression or HER2-oncogene dependence.