PRAP1 and colorectal carcinoma: Adipocyte derived exosome microsomal triglyceride transfer protein (MTTP)/proline-rich acidic protein 1 (PRAP1) complex inhibited the expression of zinc finger E-box binding homeobox 1, upregulation of glutathione peroxidase 4 and xCT, This results in a decrease in the proportion of PUFAs and lipid ROS levels, which reduces the iron death sensitivity of CRC and promotes its chemotherapy resistance to oxaliplatin [224].