In leukemia cells with high levels of CPT1 and CPT2 expression, the anti-anginal drug perhexiline inhibits FAs transport into mitochondria by inhibiting CPT, leading to depletion of phospholipids in mitochondrial membranes and impairing mitochondrial integrity, resulting in cell death in CLL [220]. Here, CPT2 is linked to B-cell chronic lymphocytic leukemia.