ACACA and Familial prostate cancer: ACC1’s acetyl-CoA carboxylase alpha (ACACA) has been found to be highly expressed in prostate cancer tissue, and it has been found that in human castration-resistant PCa (CRPC) cell lines, knockout of ACACA can reduce FAs synthesis and down-regulate mitochondrial β-oxidation, resulting in reduced ATP production and increased reactive oxygen species, leading to apoptosis [25].