FADS1 and gastric cancer: In gastric cancer, enteric gastric cancer cells express very low levels of ELOVL5 and FADS1 due to hypermethylation of the promoter region and are therefore resistant to ferroptosis, and their sensitivity to ferroptosis can be restored after PUFAs supplementation, while mesenchymal GC cells are sensitive to ferroptosis due to high levels of ELOVL5 and FADS1 [70,71].