A pivotal recent study by Yang et al. has further established the therapeutic role of Mdivi-1 in apical periodontitis, demonstrating its ability to alleviate bone erosion by inhibiting Drp1-mediated mitochondrial fission and NLRP3-dependent M1 macrophage polarisation in a Pg-LPS model.42 The gene discussed is JUP; the disease is periapical periodontitis.