CDKN1A and hydrops fetalis: Furthermore, The genetically predicted methylation of cg15474579 (located in the CDKN1A gene), cg16348358 (located in the LCK gene), and cg19869422 (located in the SMG6 gene) are all associated with an increased risk of HF, with MR estimates of 1.143 (95% CI = 1.115–1.173), 1.125 (95% CI = 1.051–1.205), and 1.103 (95% CI = 1.062–1.145), respectively.