PRDM16 and coronary artery disorder: Notably, The genetically predicted methylation level of cg01065697 (located in the PRDM16 gene and associated with PM2.5 exposure) is associated with an increased risk of MI and CHD, with MR estimates of 1.287 (95% CI = 1.162–1.425) and 1.258 (95% CI = 1.136– 1.394), respectively.