Furthermore, SGSS05-NS3 rescues p53 canonical functions specifically activating genes involved in growth arrest, apoptosis and DNA damage response (DDR) such as CDKN1A (p21), GADD45A, GADD45B, GADD45G, FAS and PMAIP (Noxa), showing strong synergy in combination with DDR-inducers chemotherapeutic drugs such as Topotecan in NB cells. The gene discussed is CDKN1A; the disease is neuroblastoma.