Consistently, SETD8 genetic inhibition by two siRNAs sequences led to an increased DDR in SY5Y NB cells as confirmed by enhanced protein levels of ɣH2AX or 53BP1 (Fig. 6G-I) and increased % of cells presenting more than 10 ɣH2AX or 53BP1 foci (Fig. 6J-L). Here, KMT5A is linked to neuroblastoma.