RNA-seq analysis data revealed that SGSS05-NS3 treatment activates p53 canonical signaling pathway in NGP MYCN-amplified NB cells, with CDKN1A (p21), TNFRSF10B, TP53INP1 and MDM2 resulting among the top differentially upregulated genes, ranked by statistical significance (FDR < 0.001) (Figure S6D). This evidence concerns the gene MYCN and neuroblastoma.