In this study, an HFD-induced obesity animal model was used to evaluate the role of FABP4 in metabolic OA, as previous studies have demonstrated the effects of HFD in inducing OA (Griffin et al. 2010, 2012; Barboza et al. 2017; Donovan et al. 2018). The gene discussed is FABP4; the disease is obesity due to melanocortin 4 receptor deficiency.