149 patients (21.4%) had preoperative CRP ≥ 10 mg/L and were more likely to be male, to have a history of cancer, were more likely to receive antibacterial medication, had a higher BMI, higher levels of S100A12, IL-6 and IL-18, and had a longer duration of anesthesia compared with the 548 patients with CRP < 10 mg/L (Table 1). This evidence concerns the gene IL18 and cancer.