In the comparison between DM_CKD and DM, mitochondrial proteins showed further alterations (MTCO2, SLC25A, ALDH9A), accompanied by decreased abundance of blood coagulation factors (F9, C9, C7), extracellular matrix remodeling proteins (COL6, FBN1, TGFB, PLG) as well as proteins involved in redox regulation (GPX3, PRDX1). This evidence concerns the gene PLG and chronic kidney disease.