In the DM group compared to controls, we observed upregulation of proteins involved in the coagulation pathway (C3, C4a, CFB, F2) and contractile proteins (ACTN1, ACTN4, MYH11) alongside the alterations of mitochondrial proteins (CPT2, SLC25A, BDH1, ALDH6 among others). This evidence concerns the gene ACTN1 and diabetes mellitus.