The strongest associations between continuous traits and risk of AS were among variants modifying lipid-relevant measures, including increased low-density lipoprotein (LDL) cholesterol (rs6511720 (prioritized to LDLR), rs11591155 (PCSK9), rs602633 (PSRC1)), lower high-density lipoprotein cholesterol (rs116843064 (ANGPTL4), rs115849089 (LPL)) and increased triglycerides (rs115849089 (LPL), rs780093 (GCKR)). This evidence concerns the gene PCSK9 and aortic stenosis.