Furthermore, in addition to the previously implicated genes in lipid metabolism and aortic stenosis (FADS2/MYRF (β = 0.047, P = 1.2 × 10−32) and SORT1/PSRC1 (β = −0.033, P = 1.6 × 10−20)), we identified variants near SORL1 (β = −0.024, P = 4.8 × 10−8), which encodes the sortilin-related receptor24. The gene discussed is FADS2; the disease is aortic stenosis.