For example, ApoB was associated with decreased AVA (β = −0.09, P = 2.2 × 10−11) and increased peak velocity (β = 0.0.8, P = 5.4 × 10−9), mean gradient (β = 0.08, P = 2.4 × 10−9; Supplementary Table 18) and risk for AS (odds ratio (OR) = 1.12, P = 5.5 × 10−13; using the pre-MTAG meta-analysis; Supplementary Table 19) using the inverse variance weighted (IVW) method. Here, APOB is linked to aortic valve stenosis.