In total, 6 of 23 loci in the recent GWAS discussed in refs. 6,19 previously associated with aortic stenosis (LPA, ACTR2, CTAGE1, TEX41, TMEM170A and APLP/WNT4) were re-identified here in association with peak velocity, mean gradient or AVA, while 1 locus for bicuspid aortic valve specifically (GATA4) was re-identified. The gene discussed is APLP1; the disease is aortic stenosis.