Of the 23 loci previously identified in refs. 6,19, we replicated all but one locus (near HMGB1) while expanding the loci for aortic stenosis by 111 further loci, including loci near PCSK9 and LDLR. We also replicate 29 of 32 loci in the recent meta-analysis of ref. 7, which also included bicuspid aortic valve. The gene discussed is LDLR; the disease is Bicuspid aortic valve.