PSEN1 and Alzheimer disease: We followed two mutant strains of AD mice, including APP/PS1 and 5×FAD with (APP/PS1-PAMAGRP120−/− versus 5×FAD-PAMAGPR120−/− mice) or without (APP/PS1-PAMAGRP120+/+ versus 5×FAD-PAMAGPR120+/+ mice) deletion of GPR120.