MLLT3 and acute myeloid leukemia: To explore whether the gene expression signature of Evi1+ iKMT2A-MLLT3 AML derived from TPO-stimulated HSC is reflected in human EVI1+ AML, we interrogated four public gene expression databases including the TARGET, BEAT, LEUCEGENE and the recently published patient cohorts from the ST.JUDE hospital45–48.