Among the DEG from the mouse model that were significantly higher expressed in at least 3 human AML cohorts were ADGRG6 (adhesion G protein-coupled receptor G6, aka GPR126), PBX1 (PBX homeobox 1) and STYK1 (Serine/Threonine/Tyrosine kinase 1) (Supplementary Data 9). The gene discussed is ADGRG6; the disease is acute myeloid leukemia.