Notably, the major histocompatibility complex (MHC) class II -associated molecule Cd74 and the suppressor of cytokine signaling 2 (Socs2) both higher expressed in cluster “ST-HSC_2” were previously connected to AML aggressiveness and stemness35,36 (Fig. 3E, Supplementary Data files 1 and 2). The gene discussed is SOCS2; the disease is acute myeloid leukemia.