CD4 and neoplasm: Moreover, flow cytometric analysis of T-cell subsets in spleen, blood, and tumor samples showed higher levels of CD8+ T cells in tumors and CD8+ and CD4+ T cells in spleens for mice treated by exosomes expressing αCD3-αEGFR PDGFR TMD fusions than those of PBS-, native exosomes-, and BP-ARC Exos-treated animals (Supplementary Fig. 19).