Bioluminescence imaging indicate rapid tumor growths on left hindlimbs of mice receiving PBS, native exosomes, and BP-ARC Exos, significantly reduced tumor progression for mice administered with αCD3-αEGFR Exos, CD9-CD38/αCD3-αEGFR Exos, and a combination (1:1) of BP-ARC Exos and αCD3-αEGFR Exos, and remarkable tumor suppression in BP-αCD3-αEGFR-ARC Exos-treated mice (Fig. 7B, C, and Supplementary Fig. 13). The gene discussed is CD38; the disease is neoplasm.