EGF and neoplasm: The results revealed that tumor spheroids were significantly smaller in EGF-treated USP11-KO HCT-15 and USP11-KO HT-29 cells compared to EGF-treated Ctrl cells (Fig. 3A, B, EGF-treated USP11-KO HCT-15 vs. EGF-treated Ctrl HCT-15; Fig. 3C, D, EGF-treated USP11-KO HT-29 vs. EGF-treated Ctrl HT-29).