In contrast, the spheroids were markedly larger in USP11-overexpressed CRC cells than in mock-transfected Ctrl cells in response to HKLM or LPS (Fig. 6E, F, USP11-overexpressed HCT-15 treated with HKLM or LPS vs. mock-transfected HCT-15 treated with HKLM or LPS; Fig. 6G, H, USP11-overexpressed HT-29 treated with HKLM or LPS vs. mock-transfected HT-29 treated with HKLM or LPS). The gene discussed is USP11; the disease is colorectal carcinoma.