Interestingly, we found that gene sets related to toll-like receptor (TLR)-mediated signaling were significantly enriched in USP11-upregulated (USP11up) CRC samples (n = 19, >2 differential expression) compared to USP11-downregulated (USP11down) CRC samples (n = 5, <-2 differential expression) (Supplementary Fig. S10A-H). Here, USP11 is linked to colorectal carcinoma.