To explore whether USP11 expression is associated with oncogenic gene sets related to CRC, 35 patients were divided into two groups: USP11-upregulated CRC (USP11up; n = 19, >2 over differential expression) and USP11-downregulated CRC (USP11down; n = 5, <-2 down differential expression) based on RNA-seq data comparing tumor and normal tissues (Fig. 1B; Supplementary Table S1; Supplementary Fig. S3A). This evidence concerns the gene USP11 and neoplasm.