Notably, immunohistochemical (IHC) staining with anti-EGFR antibodies revealed a significant reduction in EGFR expression in tumor tissues from NSG mice engrafted with USP11-KO HCT-15 cells compared to those with control HCT-15 cells (Fig. 2D, USP11-KO HCT-15 vs. Ctrl HCT-15). Here, USP11 is linked to neoplasm.