To explore the role of LRRC8/VRAC channels in tumor growth and cGAMP-mediated anti-tumor immunity, we selected the MC38 colon adenocarcinoma and B16-F10 melanoma models, which elicit different immune responses and are frequently used in related studies (19, 21, 22, 23, 45, 46). The gene discussed is LRRC8A; the disease is melanoma.