LRRC15 and cancer: We evaluated the predictive performance of HYP.SIG by comparing it with established pan-cancer models for ICI response prediction, including INFG.Sig, T.cell.inflamed.Sig, PDL1.Sig, NLRP3.Sig, LRRC15.CAF.Sig, and Cytotoxic.Sig (Fig. 5, E and F).