Hannah Egan et al.35showed that the expression of sialyltransferase, α2, 3/6-chain sialic acid, and Siglec ligand in stromal cells increased under tumor conditions, which, combined with SIGLEC9+ T-cells to inhibit T-cell action to form an immunosuppressive tumor microenvironment. This evidence concerns the gene SIGLEC9 and neoplasm.