In contrast, the severe group showed enrichment in pro-inflammatory and immune-activating pathways such as PI3K, IL8, IL-4, IL-13, ERK, and VEGF signaling play key roles in acute and chronic inflammation, contributing to diseases such as meningitis, pneumonia, sepsis, and urinary tract infections [29–32]. This evidence concerns the gene CXCL8 and susceptibility to pneumonia measurement.