Although there is a wealth of published literature attesting to the adverse prognostic effect of −7/7q8, 9 and del(17p),10, 11, 12, 13, 14, 15, 16 the independent impact of del(5q) within TP53‐mutated myeloid neoplasms outside the context of MDS with iso‐5q is poorly understood. The gene discussed is TP53; the disease is myelodysplastic syndrome.