TLR4 and Sepsis: Notwithstanding,there is no specific pharmacological treatment yet., Also some PAMPs from other infectious agents, as viruses, are recognizedby TLR4 and can cause an excessive immune response very similar toacute sepsis, leading to lethal cytokine storm. An example is the family of filoviruses (e.g., Ebola, Marburg),whose secreted glycoproteins act as TLR4 ligands, activating the inflammatorycascade., It has been recently shown that administeringTLR4 antagonists to mice challenged with Ebola can reduce the pathogenesisand lethality of the virus.,