Mining the publicly available clinical datasets, GTEx v8 (Adipose-Visceral [Omentum] and Adipose-Subcutaneous), and an obesity case–control adipose cohort (GEO accession placeholders: GSE235696, GSE213058), we observed that USP10 was significantly upregulated in adipose tissue from individuals with obesity than in the lean individuals, whereas USP13 exhibited no group-specific difference (Fig. 2a). Here, USP13 is linked to obesity due to melanocortin 4 receptor deficiency.