TAM-derived legumain exerts dual regulatory roles in glioblastoma (GBM) by promoting macrophage infiltration in an autocrine manner via the GSK3β/STAT3 pathway, while in a paracrine fashion, TAM-secreted legumain drives GBM cell proliferation and survival through integrin αv/AKT/p65 signaling [40]. This evidence concerns the gene STAT3 and glioblastoma.