We aimed to analyze the levels of serum resistin, apelin, and SREBP-1c as well as serum total cholesterol, LDL-cholesterol, HDL-cholesterol, triacylglycerol, triglycerides (TAG), glucose, and blood glycated hemoglobin A1c (HbA1c) levels in varying degrees of obesity and to investigate the changes of these analytes by applying a 3-month diet/exercise program to obese individuals. The gene discussed is SREBF1; the disease is obesity due to melanocortin 4 receptor deficiency.