Two CAR-T cells showed increased release of IFNγ, TNFα (Fig. 2E, F), IL-2 and very limited production of IL-6 (Fig. S2C, D) after stimulated by four EpCAM positive pancreatic adenocarcinoma cells while not by hTERT–HPNE. The gene discussed is IL6; the disease is pancreatic adenocarcinoma.