Pathway enrichment analysis showed that G protein-coupled receptor (GPCR) signaling, insulin secretion/resistance, and energy metabolism were among significant pathways regulated by miRNA target genes.<h4>Conclusions</h4>Patients on PD treatment showed deregulated circulating levels of the 9 identified miRNAs and higher serum inflammatory biomarkers, compared to ND patients. This evidence concerns the gene INS and Norrie disease.