EDN1 and preeclampsia: As discussed above, many of the hormones implicated in preeclampsia, including angiotensin II [246,318,319], vasopressin [35,37], and endothelin-1 [32,320] signal through GPCRs [247,248], and their associated cascades can influence the distribution and activity of class IIa HDACs [91,94–96,100].