AGT and preeclampsia: However, pregnancy and its disorders are accompanied by unique hormonal and physiological adaptations that may regulate HDAC9 itself [88,100] (including changes in angiotensin II and estrogen, which are discussed in the subsection titled GPCR Associated Kinases and Oxidative Stress as Potential Drivers of HDAC9 Dysregulation in Preeclampsia) or affect the targets it acts upon.