GSTM1 and hemorrhagic stroke: Free heme, with its central iron atom, readily partitions intolipid-rich cellular membranes where it fuels iron-dependent reactiveoxygen species (ROS) formation, lipid peroxidation, and, ultimately,cell death. However, even though thesequence of Hb → heme → lipid ROS → cell deathis now considered a key driver of neuronal loss and functional declineafter hemorrhagic stroke, it has never been experimentally delineated,providing a unique field for model development and investigation.