GJA4 and Hepatic hemangioma: Ugwu et al. identified a recurrent GJA4 c.121G>T (p.Gly41Cys) somatic mutation (in hepatic lesions) in 12 of 14 unrelated individuals with hepatic hemangiomas and in cutaneous venous malformations in three unrelated individuals. The p.Gly41Cys variant is located in the first transmembrane domain at a specific site that has remained virtually conserved among vertebrates.