CCBE1 and lymphedema: We also performed a protein-protein network analysis using the STRING (Search Tool for Retrieval of Interacting Genes/Proteins) database [18], which showed close interactions between the GJA4 gene and other genes involved in the causation of hereditary lymphedema, ADAMTS3, CCBE1, FAT4, FLT4, FOXC2, GATA2, GJA1, GJC2, KIF11, MDFIC, PIEZO1, PIK3CA, PTPN14, RASA1, SOX18, and VEGFC (Figure 7).