For example, progressive atrophy in the brainstem, the basal ganglia and later the cortex is identifiable by magnetic resonance imaging (MRI).2,3 Four-repeat tau pathology and synaptic loss associated with PSP are identifiable by positron emission tomography (PET) with second-generation tau ligands and SV2 ligands. The gene discussed is MAPT; the disease is supranuclear palsy, progressive, 1.