Specifically, post-mortem and TSPO PET studies showed that neuroinflammation co-localizes and parallels with the progression of tau pathology from subcortical to cortical regions.16,25,26 Inflammation in PSP core subcortical regions has also been shown to associate with faster clinical progression in people with PSP, considering longitudinal PSPRS scores, which captures worsening of symptoms.17 Our study expanded on the previous evidence, identifying that subcortical localized inflammation is also associated with shorter survival in people with PSP. This evidence concerns the gene TSPO and supranuclear palsy, progressive, 1.