Compared with controls, the T2DM and T2DM with MASLD patients exhibited elevated IL-6, HbA1c, FPG, and HOMA-IR levels (P < 0.001), as well as reduced HDL-C and mTOR levels (P < 0.05), while these values did not differ when comparing T2DM patients with and without MASLD (P>0.05). Here, IL6 is linked to type 2 diabetes mellitus.