In stepwise regression analyses, HbA1c and IL-6 levels were independently associated with miR-99a levels, suggesting that lower levels of this miR-99a may be related to IL-6 and HbA1c status, with all of these variables potentially shaping the onset or progression of T2DM with MASLD as a consequence of changes in miR-99a expression. This evidence concerns the gene IL6 and type 2 diabetes mellitus.