In this context, recent research places Reelin in peripheral inflammation: Hepatocyte- derived Reelin increases leukocyte adhesion and NF-κB activation especially in vascular conditions like atherosclerosis, rheumatoid arthritis, and multiple sclerosis (Calvier et al., 2020, 2023, 2024; Alexander et al., 2023). Here, RELN is linked to multiple sclerosis.