APP and Alzheimer disease: APP has emerged as an important convergence point between Reelin signaling and AD pathology: Reelin promotes APP trafficking and processing toward non-amyloidogenic pathways (Hoe et al., 2006), whereas Aβ oligomers disrupt Reelin receptor recycling and impair ApoER2-dependent phosphorylation of NMDA receptors (Durakoglugil et al., 2009).