PIEZO1 and Alzheimer disease: Furthermore, interaction analysis, evaluating Piezo1-mediated Ca2+ flux in RBCs, conventional AD biomarkers, classification of patients, memory scores, and magnetic resonance imaging (MRI) measurements, revealed positive association of the increase in the Piezo1 channel activity in RBCs with early AD-related dementia, leading to the proposal of incorporating the assessment of the RBC Piezo1 channel activity in diagnostic tests of AD is instructive in the early detection of AD-related dementia (Sitnikova et al., 2025).