Disruption of the neurovascular unit impairs oxygen and nutrient supply, as well as the clearance of neurotoxic substances, such as β-amyloid, resulting in the expression of amyloid precursor protein, capillary hypoperfusion, neurofibrillary tangle formation, neuroinflammation, neuronal damage, and cognitive deficits (Ahmad et al., 2020; Kisler et al., 2017; Nelson et al., 2016; Shabir et al., 2018). This evidence concerns the gene APP and Cognitive impairment.