Wang et al. (2023) found that IOP could significantly increase the expression levels of ubiquitin, E1, Parkin, and other ubiquitin-associated enzymes in the hippocampus of mice in a transgenic model of AD, which, in turn, increased the activity of the UPS, reduced the accumulation of amyloid aggregates, and reduced the number of AD-related symptoms. The gene discussed is PRKN; the disease is Alzheimer disease.