MYLIP and Alzheimer disease: Gao et al. (2023) therapeutically inhibited IDOL activity in the brains of AD model mice using antisense oligonucleotides (ASO) and found that the inhibition of IDOL activity resulted in a significant reduction of Aβ deposition in the brains of AD mice, upregulation of lysosomal/phagocytosis genes in microglia, and improved cognitive function of AD mice by ASO by improving the ability of improved spatial learning and memory in AD model mice.