UCHL1 and Parkinson disease: In Parkinson’s disease, mutated UCHL1 causes a variety of pathological conditions: protein degradation caused by loss of catalytic function is blocked, abnormal protein interaction affects mitochondrial autophagy, molecular chaperone-mediated autophagy, etc., and oxidatively modified UCHL1 aggregates to form a pathological protein network (Buneeva and Medvedev, 2024).