The pathogenesis of AD has not been clearly elucidated, and the current mainstream theories include the amyloid cascade hypothesis, the Tau protein phosphorylation hypothesis, the cholinergic hypothesis, the mitochondrial cascade hypothesis, etc. (Tiwari et al., 2019; Ju and Tam, 2022; Ashleigh et al., 2023). The gene discussed is MAPT; the disease is Alzheimer disease.