Chun Loong Ho et al. reprogrammed the EcN to bind to the heparan sulfate proteoglycan (HSPG) on the cancer cell surface and to secrete myrosinase for the conversion of glucosinolate to sulforaphane [16], which promotes apoptosis in cancer cells and results in colorectal tumor clearance in murine models [16]. The gene discussed is CD44; the disease is cancer.