Several reports have indicated that mitochondrial dysfunction is involved in DCM (Peng et al., 2023; Cai et al., 2024) and that TSPO (Musman et al., 2017; Fu et al., 2020) and FTMT (Wang P. et al., 2022) are essential for maintaining myocardial mitochondrial homeostasis. Here, TSPO is linked to familial dilated cardiomyopathy.