In chronic kidney disease, vascular calcification characterized by calcium deposition and vascular smooth muscle cell osteogenic transdifferentiation, is attenuated by Rb1 via regulation of the PPARγ/Wnt/β-catenin axis in both chronic kidney disease-induced vascular calcification rats and β-glycerophosphate-stimulated vascular smooth muscle cells (Zhou et al., 2019). This evidence concerns the gene PPARG and chronic kidney disease.