Other reports show that Rg1 suppresses NOX4-MAPK and TRPC6-ChREBP-TXNIP pathways to limit lipid deposition, ROS accumulation, and glycoprotein deposition in T2DM-associated fibrosis (Ji et al., 2023; Zhang H. et al., 2025). Here, TRPC6 is linked to type 2 diabetes mellitus.