Collectively, ginsenosides Rg1, Rb1, and Rk1 confer multi-faceted renoprotection against sepsis-induced acute kidney injury through multiple mechanisms, including TLR4, NF-κB, NLRP3, STAT1/3, and ferroptosis-associated pathways (Table 2; Figure 1B). Here, TLR4 is linked to Sepsis.