For example, pathologists who underwent specific reader training to score PD-L1 using TPS or CPS with PD-L1 IHC 22C3 pharmDx showed high overall interobserver agreement across several tumor types (83, 84); interobserver agreement was ≥87.3% for TPS (83) and ≥86.5% for CPS (82). This evidence concerns the gene CD274 and neoplasm.