The low PFS (2-years PFS: 59%) can be attributed to the high rate of PD-L1 negative patients (62%), the relatively high representation of tumors over 3cm (40%), and more importantly, the fragility of the population, as demonstrated by an ECOG 2 rate of 15%, which led to a high incidence of death from intercurrent illness without tumor progression. Here, CD274 is linked to neoplasm.