The surgery not only successfully resected the recurrent tumor (with a maximum diameter of 12.5 cm), achieved complete survival of the bilateral myocutaneous flaps, and eliminated RVF symptoms, but also enabled the preoperative intractable HCM to spontaneously return to the normal range on the 3rd postoperative day, with a significant decrease in serum squamous cell carcinoma antigen (SCC). This evidence concerns the gene SERPINB3 and neoplasm.