NLRP3 and corneal infection: However, we and others have identified striking differences in inflammasome activation between neutrophils and macrophages, including that whereas NLRP3 activation of macrophages results in pyroptotic cell death, neutrophils were the primary source of IL-1β following canonical NLRP3 activation or corneal infections with P. aeruginosa, Streptococcus pneumoniae, or Salmonella typhimurium and that neutrophils activated under identical in vitro conditions as macrophages do not undergo pyroptosis following canonical NLRP3 activation47–50.