Early detection and targeted treatment are crucial to combat PCa lethality, particularly in high-risk populations.16 Here, we present evidence that PCa in AA/B men is associated with GLO1 SNP rs1049346, a variant located in the 5 ́ UTR region of the GLO1 gene and found to be homozygous in the MDA-PCa-2b cell line. This evidence concerns the gene GLO1 and posterior cortical atrophy.