A key limitation of prior studies is that they do not capture GLO1 enzymatic activity, which can be impacted by single nucleotide polymorphisms (SNPs).9, 10 In patients with type 2 diabetes, SNP rs1049346 was significantly associated with diabetic nephropathy and retinopathy, and lower GLO1 expression and activity.11 However, the association between SNP rs1049346 and PCa has not been addressed. The gene discussed is GLO1; the disease is diabetic kidney disease.