TXNIP is a well-established MG-responsive gene that increases when NRF2-driven antioxidant capacity is low.23 Indeed, NRF2 directly binds an ARE located upstream to TXNIP promoter to downregulate its expression under basal and high glucose.24 Thus, TXNIP upregulation in MG-treated in MDA-PCa-2b cells compared to C4–2 cells may reflect an overall inhibition of NRF2 activity in these cells. Here, TXNIP is linked to posterior cortical atrophy.