GLO1 and retinal disorder: A key limitation of prior studies is that they do not capture GLO1 enzymatic activity, which can be impacted by single nucleotide polymorphisms (SNPs).9, 10 In patients with type 2 diabetes, SNP rs1049346 was significantly associated with diabetic nephropathy and retinopathy, and lower GLO1 expression and activity.11 However, the association between SNP rs1049346 and PCa has not been addressed.