This analysis identified different TSG classes, including those (1) predominantly affected by homozygous deletions, including SMAD4 in STAD, RB1 in BLCA, and NOTCH1 in HNSC; (2) predominantly affected by co-occurring mutation/CNDs, including TP53 in LIHC/LUAD/STAD, VHL in KIRC, and PTEN in GBM (Figure 1F, Table S1G). Here, SMAD4 is linked to bladder transitional cell carcinoma.