Studies by Huang et al. (2014) using the non-small cell lung carcinoma (NSCLC) cell line showed that Myeloid cell leukemia-1 (Mcl-1) binds strongly to VDAC1 and 3 and appears to have a higher affinity for VDAC1 than Bcl-xL (Huang et al., 2014). This evidence concerns the gene BCL2L1 and non-small cell lung carcinoma.