SPP1 and neoplasm: We found that while the C1QC TAM signature markers (APOE, C1QC, C1QB, C1QA, TREM2, MRC1, CD163, MERTK) contain genes that are specific for macrophages, some markers attributed to SPP1 TAMs (SPP1, PPARG, ADM, MARCO, VEGFA, VCAN, CXCL8, ANGPTL4) are also highly expressed in tumor and stromal cells, making them inappropriate to detect SPP1 TAMs from bulk sequencing data (Supplementary Figure 5A).