CASP3 and neoplasm: Similarly, key apoptosis genes (BCL2, CASP3, CASP8 and CASP9) were upregulated in M0 and M1 macrophages in DLBCL compared with control samples (tumor/control fold change: 3.7e+01 to 6.0e+01, p ≤2.0e-15 for M0; 4.5e+02 to 1.4e+03, p ≤1.0e-15 for M1, respectively), but not in M2 macrophages (tumor/control fold change: 3.2e-01 to 5.3e-01, p ≤1.e-15) (Figure 3B, Table 1).