SPP1 and neoplasm: These upregulated genes (KRT7, KRT81, SPP1, PCDH7, SLC2A1, TET1, FKBP4, FSCN1, and GRIP1) were expressed at higher levels in tumor tissues than in adjacent normal tissues, which indicated a poor prognosis and shorter survival of LUAD patients according to TCGA predictions (http://gepia.cancer-pku.cn/) (Figures 3D, E).