CADM1 and neoplasm: Notably, compared with normal tissues, tumor tissues exhibited high levels of ligand–receptor interactions, especially putative FN1–CD44 interactions in the FN1 signaling pathway and putative CADM1-CADM1 interactions in the CADM signaling pathway, which may be able to recruit immune cells into the TME and inhibit tumor progression (Figures 6E, F).