Notably, compared with normal tissues, tumor tissues exhibited high levels of ligand–receptor interactions, especially putative FN1–CD44 interactions in the FN1 signaling pathway and putative CADM1-CADM1 interactions in the CADM signaling pathway, which may be able to recruit immune cells into the TME and inhibit tumor progression (Figures 6E, F). Here, FN1 is linked to neoplasm.