Recent studies show that low-dose radiotherapy (LDRT) combined with PD-1 inhibitors can induce stem-like CD8+ T cells from tumor-draining lymph nodes (TDLN) to the tumor and differentiate into CXCR6+ effector subpopulations, generating an abscopal effect, and forming long-term immune surveillance (97, 98). Here, CXCR6 is linked to neoplasm.