CD8A and neoplasm: IFN-α/β paracrinally up-regulates MHC-I on tumor cells, enhances dendritic-cell (DC) maturation and cross-presentation, diminishes regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs) populations, and—via the CXCL10–CXCR6 axis—recruits CXCR6+ CD8+ effector T cells into the tumor bed.